How Glucocorticoids Effectivity Is Improved by taking Magnesium
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Magnesium Insufficiency
Insufficient magnesium intake on your diet is linked to a greater risk of heart disease. Studies have shown that stiffness in arteries improves after taking magnesium supplements for a long period of time. This may be why magnesium has been linked to a reduced risk of heart disease.
Role of Cortisol in Heart Disease Risk
Studies have shown the role of cortisol in heart disease risk. For example, people with Cushing’s syndrome (too much cortisol) have changes in their blood vessels, including increased stiffness and problems with the endothelium (a layer of cells that line blood vessels).
Several enzymes that help regulate cortisol levels in the body have been linked to the development of metabolic syndrome, which is a risk factor for heart disease. The 11β‐HSDs enzyme helps convert inactive cortisone to active cortisol, while the A‐ring reductases enzyme helps convert cortisol and cortisone to their metabolites.
These enzymes can be measured by looking at the levels of cortisol, cortisone, and their metabolites in urine over a 24‐hour period. This provides information about how much cortisol is being produced and cleared by the body.
A study was conducted on the effects of magnesium supplementation on glucocorticoid metabolism. The study looked at the 24-hour urinary excretion of cortisol, cortisone, and their metabolites, as well as enzyme activity of 11β-HSD and A-ring reductases.
The Study on Magnesium and its Effects on Cortisol, Cortisone and Metabolites
49 participants produced data on 24-hour urinary cortisol, cortisone, and metabolites. The average age was 62 years, and 44.9% were female. The average BMI was 29 kg/m2.
There were no significant differences between the magnesium and placebo groups at baseline. Oral magnesium supplementation increased 24-hour urinary magnesium excretion by 2.22 mmol/24-hours.
There was a small but non-significant increase in plasma magnesium. Compliance was excellent, and the magnesium supplements were well tolerated.
The Results
After 24 weeks of magnesium supplementation, urinary cortisol excretion decreased in the magnesium group compared to the placebo group. Ratios of THFs/THE and cortisol/cortisone were decreased following magnesium supplementation by 0.09 and 0.10, respectively.
No effects were observed on A-ring reductase activity.
Conclusion
In conclusion, magnesium supplements seem to positively affect reducing cortisol levels and increasing the activity of the enzyme 11β-HSD type 2. This could lead to a reduced risk of heart disease.
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